Di Zenzo G, Della Torre R, Zambruno G, Borradori L. Histopathologically eosinophil infiltration in the super and deep dermis was found. DEB is the second most common form of EB, the first being EB simplex. Always seek the advice of your own physician or other qualified health care professional regarding any medical questions or conditions. Although there is no increase in maternal mortality, there is an association with premature birth of the affected neonate and low birth weight, which has been upheld by several studies. But the recurrence is quite mild. This is a hive-type reaction that commonly begins in the third trimester.
pp. The blisters typically cluster into groups. Subepidermal blisters may result in ulceration and scarring following rupture. Most often these lesions occur in a characteristic configuration giving a “cluster of jewels” or “string of pearls” appearance. It popped in right after a radiofrequency ablation to my cervical spine for cervical spondylitis & radiculopathy right at the shot site! Coomb’s positive autoimmune hemolytic anemia with giant cell hepatitis (GCH) is a rare disease entity that can progress rapidly and cause fatality. Macules appear in the first to second decade and are typically non-progressive.
Genital herpes is typified by blisters, lesions and soreness in the vaginal area, penis and scrotum. It is also important to point out that there is no absolute cure for herpes simplex virus. The discomfort makes eating and drinking difficult. Do you have any tips on how to figure out how something will look on you when you don’t have the same body type as the model? Skin lesions progress over hours in a centripetal fashion from erythematous macules and papules to vesicles and ending with crusted scabs. The vesicular stage is often referred to as “dew drops on a rose petal” [Figure 4]. Bullous pemphigoid and pemphigus vulgaris – incidence and mortality in the UK: population based cohort study.
Direct immunofluorescence showed no findings of immunobullous diseases. Management is preventive: protective padding of the skin and careful wound care reduce blistering, scarring and prevent secondary infection. Extraoral manifestations of systemic sclerosis include thinned out lips and microstomia along with perioral radiating furrows (rhagades) giving a “fish mouth or purse string” appearance to the oral aperture [Figure 7]. Pseudopelade of Brocq is a primary lymphocytic scarring alopecia characterized by skin-colored patches of cicatricial alopecia with minimal perifollicular inflammation. Clinically, the condition is characterized by multiple, asymptomatic, 1-2 cm patches of cicatricial alopecia, giving a footprints in snow appearance [Figure 8]. Mid-borderline (BB) Hansen disease consists of multiple asymmetrical and polymorphic lesions. A classical book descriptions of BB leprosy is that of a variable-sized plaque having sloping outer edges and a punched out central edge giving the so-called inverted saucer appearance [Figure 10].
Multiple pustular lesions coalescing together over an erythematous base are seen in pustular psoriasis. Acute generalized or localized eruptive pustulosis (AGEP) following intake of cephalosporins, terbinafine, and vancomycin may also simulate the lake of pus appearance of lesions as seen in pustular psoriasis [Figure 11]. Diffuse cutaneous mastocytosis is an extremely rare variant of cutaneous mastocytosis characterized by infiltration of skin by mast cells giving it a thickened and doughy appearance. The combined result of both the infiltration of mast cells and their degranulation products produces edema and a typical leather-grain skin appearance ,[Figure 12]. Although designated as status 1 for liver transplantation, no organ became available and he received a living related liver transplant from his mother five days after admission. The variable size and shape of geographic tongue with frequent change in position has been referred as ‘map-like’ appearance.  It has been proposed that benign migratory glossitis is an isolated oral manifestation of psoriasis.
Geographic tongue may also be seen in other conditions like Reiter’s syndrome, Down syndrome, Aarskog syndrome, fetal hydantoin syndrome and Robinow’s syndrome. The most common causes of death in pemphigus nowadays are adverse reaction to drugs and infections. This button up blouse is everything I want in a shirt. A hair, or part of one, is usually embedded in the horny center. The eruptions have a predilection for the sides of the neck and trunk, the extensor surfaces of the extremities and especially the backs of the first and second phalanges. Dermatol. The disorder was proposed the following defining criteria : (a) pruritic papules, nodules and/or vesiculobullous eruption refractory to conservative treatment; (b) eosinophil-rich lymphohistiocytic infiltrate in superficial and deep dermis; (c) excluding other causes of tissue eosinophilia and (d) preexisting diagnosis of a hematologic malignancy or dyscrasia or its subsequent development.
Macular amyloidosis shows brown, rippled macules characteristically located in the interscapular region of the back, arms, and legs. The pigmentation is not uniform giving the lesions a rippled appearance [Figure 14]. Salt and pepper appearance may also be seen as a feature of quadrichrome vitiligo which is characterized by depigmented and hypopigmented macules in addition to normally pigmented skin with the additional presence of marginal or perifollicular hyperpigmentation. This is observed, particularly in areas of repigmentation in lesions of vitiligo [Figure 16]. Multiple shallow pits over the nail plate give it a rough look likened to sandpaper. This may be observed to involve a few or all nails as in 20 nail dystrophy or trachyonychia. The most common dermatologic diseases associated with trachyonychia are alopecia areata, lichen planus and psoriasis [Figure 17].
Erythema infectiosum (also known as fifth disease) is a benign childhood infection caused by parvovirus-B19. After about 7-10 days, the infection progresses through stages of an exanthem with classic slapped-cheek appearance which fades over 2-4 days.  This is followed by an erythematous maculopapular rash that fades into a classic lace-like reticular pattern as confluent areas clear up in a lacy pattern. Direct fluorescence antigen and immunoglobulin M antibody titers for herpes simplex virus were negative. This disappears by the fourth or fifth day leaving a bright red strawberry appearance.  Similar “strawberry” tongue is also seen in the streptococcal-mediated infection, scarlet fever [Figure 20].