Genital Herpes

Lesson of the week: Interpretation of rubella serology in pregnancy—pitfalls and problems

The TORCH (Toxoplasma gondii, Rubella, Cytomegalovirus (CMV) and the Herpes Simplex Virus) cause range of diseases in pregnant women and HIV patients and lead to adverse fetal outcomes when not treated on time, in HIV positive can cause life threating infections. To monitor the progress toward elimination, surveillance is critical. Herpes simplex virus (HSV) is often the cause of neurological, somatic inbsp; unbsp endocrine problems; newborns inbsp; older children [3]. In this low-prevalence population, the positive predictive value of the Focus HSV-2 ELISA test was low. The aims of this paper were to determine the serological response to HSV-1 and HSV-2 infection among pregnant women and women of reproductive age and seroprevalence of HSV-1 and HSV-2 antibodies among pregnant women and women of reproductive age. Because of its high molecular weight, IgM is found most commonly in the intravascular compartment and is not transported to the fetus. Toxoplasmosis.

Five patients were referred from outside the United Kingdom, four because rubella specific IgM had been detected in the absence of a rash. Six seroconversions were observed: two VZV, one CMV and three parvovirus infections. Pregnancy related conditions, such as intrahepatic cholestasis of pregnancy (ICP), pre-eclampsia, HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome, and acute fatty liver of pregnancy (AFLP) [1], almost always occur during the third trimester. Patient 6 presented with rash and fever at 33 weeks’ gestation. A vesicular scrape was taken and a diagnosis of chickenpox made by immunofluorescence. This effect was most apparent among women at high risk for HSV-2 infection. Such false positive IgM results may be explained by cross reacting antibodies known to be induced by some viral infections and autoimmune disease.6,9,13 It is therefore of interest that this patient gave a weak positive result in the Rose Waaler assay and during childhood had suffered from rheumatic fever and required mitral valve replacement.


Educating young women about HSV-2 infection may help in reducing its burden in this semi-urban population. Enders G. Qualitätssicherung in der Serodiagnostik bei der Mutterschaftsvorsorge: Qualitätssicherung und aktuelle Aspekte zur Serodiagnostik der Röteln in der Schwangerschaft. There were 366 cases of herpes zoster in pregnancy, of which 119 occurred in the first 36 weeks of gestation. Symposium am 04. At the laboratory of a tertiary care hospital, over a two and a half year period, subsets of 891 sera samples collected from patients for the detection of the IgM and IgG for TORCH and were analyzed qualitatively by commercially available ELISA kits. There were no statistically significant differences (z-test) between the sensitivities (95% confidence intervals [CIs]) of the Meddens (76.8% [95% CI, 72.2%–81.4%]), Behring (75.9% [95% CI, 71.3%–80.6%]), Wampole (74.1% [95% CI, 69.3% 78.9%]), and Diamedix (76.1% [95% CI, 71.3%–80.9%]) assays.

Unbsp; 22 (30%) of pregnant women was found the only pathogen IGO: Ureaplasma urealiticumnbsp; unbsp; 15 (20,4%), Micoplasma hominisnbsp; unbsp; 4 (5.4%). Most individuals infected with HSV-1 or HSV-2 are asymptomatic or have very mild symptoms that go unnoticed or are mistaken for another skin condition. Enders G. IgM testing for HSV is not advised, as the presence of IgM does not correlate with acute disease. J Clin Microbiol 1984; 20: 525-529. Pränatal- und Geburtsmedizin. Berichte vom 5.

Kongreß der Gesellschaft für Pränatal- und Geburtsmedizin vom 21. bis 23. Februar 1997. Meckenheim: DCM Druck Center; 1998. pp. 76–82. 13.

Enders G, Miller E. That’s the major reason that mothers with recurrent genital herpes rarely transmit herpes to their babies during delivery. In: Arvin AM, Gershon AA, editors. With a seroprevalence for HSV IgM and IgG being 13.44% and 25.51% respectively, it is indicative of the scope for interventions (Prevention among Positives).14 HSV Type II IgG positivity is seen about 10.10% in a small survey conducted by sample size of 2546.15 Rubella antibodies both IgM (6.44% and IgG (28%) were positive and prevalence rates was not higher for IgG antibodies in our study when compared in antenatal cases. Thus, interpretation of results is dependent on the timing of sample collection relative to disease onset.